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Kevin Atchison Selected Research

Alzheimer Disease (Alzheimer's Disease)

12/2017Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
10/2016Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors.
4/2015Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors.
3/2015Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.
1/2013Effects of the γ-secretase inhibitor semagacestat on hippocampal neuronal network oscillation.
7/2012Age-dependent disruption in hippocampal θ oscillation in amyloid-β overproducing transgenic mice.
11/2009Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
12/2008Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
11/2008Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels.
6/2008Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.

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Kevin Atchison Research Topics

Disease

10Alzheimer Disease (Alzheimer's Disease)
12/2017 - 06/2008
2Amyloid Plaque
07/2012 - 11/2009
1Toxic Optic Neuropathy
10/2016
1Mental Disorders (Mental Disorder)
01/2013
1Cerebral Amyloid Angiopathy (Congophilic Angiopathy)
11/2009
1Disease Progression
11/2008
1Astrocytoma (Pilocytic Astrocytoma)
11/2008

Drug/Important Bio-Agent (IBA)

6Amyloid Precursor Protein Secretases (beta-Secretase)IBA
12/2017 - 12/2008
3Amyloid (Amyloid Fibrils)IBA
07/2012 - 06/2008
2Pharmaceutical PreparationsIBA
10/2016 - 01/2013
2Amyloid beta-PeptidesIBA
11/2009 - 06/2008
2begacestatIBA
11/2009 - 12/2008
1Cathepsin DIBA
10/2016
1N2- ((2S)- 2- (3,5- difluorophenyl)- 2- hydroxyethanoyl)- N1- ((7S)- 5- methyl- 6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- L- alaninamideIBA
01/2013
1Proteins (Proteins, Gene)FDA Link
11/2009
1SulfonamidesIBA
11/2009
1ThiophenesIBA
11/2009
1Peptides (Polypeptides)IBA
11/2009
1Apolipoprotein E3IBA
11/2008
1Apolipoprotein E4IBA
11/2008
1Apolipoproteins E (ApoE)IBA
11/2008